Alterações na capacidade antioxidante, níveis de peroxidação lipídica e nitritos em pacientes com Diabetes tipo 2
DOI:
https://doi.org/10.15448/1980-6108.2024.1.45632Palavras-chave:
diabete mellitus, hiperglicemia, estresse oxidativo, nitritosResumo
Objetivos: este estudo de caso-controle busca investigar marcadores oxidativos, capacidade antioxidante e níveis de glicose em pacientes com Diabetes mellitus tipo 2 (T2DM), em comparação com participantes saudáveis de perfil semelhante. Adicionalmente, analisa-se o impacto da glicose nessas variáveis. Metodologia: foram incluídos 20 pacientes com T2DM e hiperglicemia, bem como 20 voluntários saudáveis no grupo controle (CG). Nos participantes, os níveis de glicose, malondialdeído, nitritos e capacidade antioxidante total (TAC) foram determinados no plasma. Para analisar diferenças significativas entre as variáveis nos grupos, aplicaram-se o teste t de Student ou Mann– Whitney. O teste de correlação linear de Pearson foi empregado para avaliar associações entre as variáveis. Resultados: os níveis de glicose e TAC mostraram elevação significativa no grupo T2DM em comparação com o CG. Participantes do grupo T2DM apresentaram redução nos níveis de malondialdeído e nitritos (1,83±0,84 µM/L e 29,5 ± 16,6 µmol/L, respectivamente) em relação ao CG (4,00±1,11 µM/L e 82,9±29,2 µmol/L, respectivamente), ambos demonstrando forte correlação positiva (p = 0,0002). Conclusão: pacientes com Diabetes mellitus tipo 2 exibem alterações no estado redox, evidenciadas pela diminuição da peroxidação lipídica e dos níveis de nitritos, indicando comprometimento na via constitutiva de produção de óxido nítrico. Esses achados ressaltam a complexa relação entre estresse oxidativo, antioxidantes e metabolismo da glicose.
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